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Is Alpha-casozepine Efficacious at Reducing Anxiety in Dogs?

Louise Anne Buckley

Published:  18/07/2017    in:  Knowledge Summaries

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Clinical bottom line

There is currently no evidence to show that alpha-casozepine is effective as an anxiolytic when administered to dogs shortly (minutes to a few days) before exposure to an anxiety provoking stressor. There is limited and weak evidence to suggest that it may have a role to play in reducing anxiety in dogs over the medium to longer term but the available evidence is of low quality and / or high risk of bias, with confounding variables providing alternative explanations for the findings. More research is needed in this area.

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  1. Beata, C. et al. (2007) Effects of alpha-casozepine (Zylkene) versus selegiline hydrochloride (Selgian, Anipryl) on anxiety disorders in dogs. Journal of Veterinary Behaviour: Clinical Applications and Research, 2 (5), pp. 175-183
  2. Kato, M. et al. (2012) Effects of prescription diet on dealing with stressful situations and performance of anxiety-related behaviors in privately owned anxious dogs. Journal of Veterinary Behavior: Clinical Applications and Research, 7 (1), pp. 21-26
  3. Pageat, P. (1995) Pathologie du comportement du chien. Editions du Point Veterinaire, Maisons-Alfort: 208 – 224
  4. Palestrini, C. et al (2010) Efficacy of a diet containing caseinate hydrolysate on signs of stress in dogs. Journal of Veterinary Behavior, 5 (6), pp. 309-317

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Copyright (c) 2017 Louise Anne Buckley

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