DOI
https://doi.org/10.18849/ve.v1i1.8Abstract
Clinical bottom line
There remains until recently an overall lack of clarity for the practical criteria for the diagnosis of canine idiopathic epilepsy. Signalment and an interictal neurological examination are vital for the diagnosis of idiopathic epilepsy. Despite the current insufficient evidence, the emerge of new diagnostic methods, such as cerebrospinal fluid and/or serum biomarkers, advanced functional neuroimaging techniques and electroencephalography, is likely to change the diagnostic approach in canine epilepsy in the near future.
References
Armaşu, M., et al. (2014) An exploratory study using a statistical approach as a platform for clinical reasoning in canine epilepsy The Veterinary Journal, 202 (2), pp. 292–296 http://dx.doi.org/10.1016/j.tvjl.2014.08.008
Akos, P. et al. (2012) Electroencephalographic examination of epileptic dogs under propofol restraint. Acta Veterinaria Hungarica, 60 (3), pp. 309-324 http://dx.doi.org/10.1556/AVet.2012.026
Bartels, J. et al. (2014). MIP-3beta/CCL19 is associated with the intrathecal invasion of mononuclear cells in neuroinflammatory and non-neuroinflammatory CNS diseases in dogs. BMC Veterinary Research, 10:157 http://dx.doi.org/10.1186/1746-6148-10-157
Berendt, M., et al. (2015) International veterinary epilepsy task force consensus report on epilepsy definition, classification and terminology in companion animals. BMC Veterinary Research, 11:182 http://dx.doi.org/10.1186/s12917-015-0461-2
Brauer, C., et al. (2012) Electroencephalographic recordings in dogs suffering from idiopathic and symptomatic epilepsy: diagnostic value of interictal short time EEG protocols supplemented by two activation techniques. The Veterinary Journal, 193 (1), pp. 185-192 http://dx.doi.org/10.1016/j.tvjl.2011.10.006
Browand-Stainback, L., Levesque, D. and McBee, M. (2011) Canine and feline epileptic seizures and the lunar cycle: 2,507 seizures (2000-2008). Journal of the American Animal Hospital Association 47(5), pp.324-328 http://dx.doi.org/10.5326/JAAHA-MS-5591
Calvo, D. B. (2012) Study of C-reactive protein concentrations in serum and cerebrospinal fluid in dogs with idiopathic epilepsy. Masters dissertation, Faculdade de Medicina Veterinaria e Zootecnia, Universidade de Sao Paulo,
Casal, M. L., et al (2006) Epilepsy in Irish Wolfhounds. Journal of Veterinary Internal Medicine, 20(1), pp.131-135 http://dx.doi.org/10.1111/j.1939-1676.2006.tb02832.x
Creevy, K. E., et al (2013) Comparison of concentrations of gamma -aminobutyric acid and glutamate in cerebrospinal fluid of dogs with idiopathic epilepsy with and without seizure-related magnetic resonance imaging hyperintense areas in the limbic system. American Journal of Veterinary Research, 74(8), pp 1118-1125 http://dx.doi.org/10.2460/ajvr.74.8.1118
De Risio, L. et al. (2015) International veterinary epilepsy task force consensus proposal: diagnostic approach to epilepsy in dogs. BMC veterinary research, 11:148 http://dx.doi.org/10.1186/s12917-015-0462-1
Ekenstedt, K. J., et al (2011) Candidate genes for idiopathic epilepsy in four dog breeds. BMC Genetics, 12:38 http://dx.doi.org/10.1186/1471-2156-12-38
Ellenberger, C., et al 2004) Inhibitory and excitatory neurotransmitters in the cerebrospinal fluid of epileptic dogs. American Journal of Veterinary Research, 65(8). pp.1108-1113 http://dx.doi.org/10.2460/ajvr.2004.65.1108
Fredsø, N., et al (2014) Risk factors for survival in a university hospital population of dogs with epilepsy. Journal of Veterinary Internal Medicine, 28(6), pp.1782-1788 http://dx.doi.org/10.1111/jvim.12443
de la Fuente, C.et al. (2012) Fibrinolytic activity in cerebrospinal fluid of dogs with different neurological disorders. Journal of Veterinary Internal Medicine,, 26(6), pp. 1365-1373 http://dx.doi.org/10.1111/j.1939-1676.2012.00991.x
Fujiwara, K., et al (2008) Autoantibodies against glial fibrillary acidic protein in canine sera. Veterinary Record, 162(18), pp. 592-593 http://dx.doi.org/10.1136/vr.162.18.592
Gesell, F. K., et al (2013) Alterations of endocannabinoids in cerebrospinal fluid of dogs with epileptic seizure disorder. BMC veterinary research, 9:262 http://dx.doi.org/10.1186/1746-6148-9-262
Ghormie, T.M., Feldman, D.G. and Cook, J.R. (2015) Epilepsy in dogs five years of age and older: 99 cases (2006–2011). Journal of the American Veterinary Medical Association.,246(4), pp. 447-450 http://dx.doi.org/10.2460/javma.246.4.447
Goncalves, R., et al (2010) Effect of seizures on cerebrospinal fluid analysis in dogs with idiopathic epilepsy. Veterinary Record,166(16), pp. 497-498 http://dx.doi.org/10.1136/vr.b4812
Hall, S. J. G. and Wallace, M. E. (1996) Canine epilepsy: a genetic counselling programme for Keeshonds. Veterinary Record, 138(15), pp.358-360 http://dx.doi.org/10.1136/vr.138.15.358
Hülsmeyer, V. I. et al. (2015) International Veterinary Epilepsy Task Force’s current understanding of idiopathic epilepsy of genetic or suspected genetic origin in purebred dogs. BMC veterinary research, 11:175 http://dx.doi.org/10.1186/s12917-015-0463-0
Hasegawa, T., et al (2014) Gas chromatography-mass spectrometry-based metabolic profiling of cerebrospinal fluid from epileptic dogs. The Journal of veterinary medical science 76(4), pp.517-522. http://dx.doi.org/10.1292/jvms.13-0520
Holliday, T.A. and Williams, D.C. (1998) Interictal paroxysmal discharges in the electroencephalograms of epileptic dogs. Clinical Techniques in Small Animal Practice,13(3), pp.132-143 http://dx.doi.org/10.1016/S1096-2867(98)80034-0
Jaggy, A., et al (1998a) Genetic aspects of idiopathic epilepsy in Labrador retrievers. Journal of Small Animal Practice 39(6), pp.275-280 http://dx.doi.org/10.1111/j.1748-5827.1998.tb03650.x
Jaggy, A. and Bernardini, M. (1998b) Idiopathic epilepsy in 125 dogs: a long-term study. Clinical and electroencephalographic findings. Journal of Small Animal Practice., 39(1), pp.23-29 http://dx.doi.org/10.1111/j.1748-5827.1998.tb03665.x
Jokinen, T. S., et al (2007) Benign familial juvenile epilepsy in Lagotto Romagnolo dogs. Journal of Veterinary Internal Medicine 21(3), pp. 464-471 http://dx.doi.org/10.1111/j.1939-1676.2007.tb02991.x
Kathmann, I. et al (1999) Clinical and genetic investigations of idiopathic epilepsy in the Bernese mountain dog. Journal of Small Animal Practice. 40(7), pp.319-325 http://dx.doi.org/10.1111/j.1748-5827.1999.tb03089.x
Kloene, J., et al (2008) Clinical investigations of seizures in Border Terriers. Kleintierpraxis, 53(1), pp. 5-12
Koutinas, A. F., Polizopoulou, Z. S. and Kontos, V. I. (1994) Clinical and clinicopathological evaluation in 14 dogs with presumed idiopathic epilepsy. Bulletin of the Hellenic Veterinary Medical Society 45(2), pp.141-149
Lengweiler, C. and Jaggy, A. (1999) Clinical, epidemiological and therapeutic aspects of idiopathic epilepsy in 25 Golden Retrievers: results of a long-term study. Schweizer Archiv fur Tierheilkunde, 141(5), pp.231-238
Licht, B. G., et al (2007) Clinical characteristics and mode of inheritance of familial focal seizures in Standard Poodles. Journal of the American Veterinary Medical Association, 231(10), pp. 1520-1528 http://dx.doi.org/10.2460/javma.231.10.1520
Lobert, V., Mischke, R. and Tipold, A. (2003) Lactate and pyruvate levels in blood and cerebrospinal fluid. Kleintierpraxis, 48(12), pp. 735-743
Matiasek, K. et al. (2015) International veterinary epilepsy task force recommendations for systematic sampling and processing of brains from epileptic dogs and cats. BMC Veterinary Research, 11:216 http://dx.doi.org/10.1186/s12917-015-0467-9
Merbl, Y.,et al (2014) Tumor necrosis factor-α and interleukin-6 concentrations in cerebrospinal fluid of dogs after seizures. Journal of Veterinary Internal Medicine 28(6), pp.1775-1781 http://dx.doi.org/10.1111/jvim.12462
Morita, T., et al (2002) Cliniconeuropathologic findings of familial frontal lobe epilepsy in Shetland sheepdogs. Canadian Journal of Veterinary Research, 66(1), pp. 35-41
Oberbauer, A.M., et al (2003) The genetics of epilepsy in the Belgian tervuren and sheepdog. Journal of Heredity, 94(1), pp.57-63 http://dx.doi.org/10.1093/jhered/esg010
Pákozdy, A., et al (2006) Seizures in boxer - a retrospective study (1999-2005). Wiener Tierarztliche Monatsschrift, 93, pp.270-276
Pákozdy, A., et al. (2008) Retrospective clinical comparison of idiopathic versus symptomatic epilepsy in 240 dogs with seizures. Acta Veterinaria Hungarica 56(4), pp.471-483 http://dx.doi.org/10.1556/AVet.56.2008.4.5
Patterson, E. E., et al (2005) Clinical description and mode of inheritance of idiopathic epilepsy in English Springer Spaniels. Journal of the American Veterinary Medical Association, 226(1), pp. 54-58 http://dx.doi.org/10.2460/javma.2005.226.54
Patterson, E.E., et al (2003) Clinical characteristics and inheritance of idiopathic epilepsy in Vizslas. Journal of Veterinary Internal Medicine 17(3), pp.319-325 http://dx.doi.org/10.1111/j.1939-1676.2003.tb02455.x
Podell, M. and Hadjiconstantinou, M. (1997) Cerebrospinal fluid gamma-aminobutyric acid and glutamate values in dogs with epilepsy. American Journal of Veterinary Research, 58(5), pp. 451-456
Podell, M., Fenner, W. R., and Powers, J. D. (1995) Seizure classification in dogs from a nonreferral-based population. Journal of the American Veterinary Medical Association 206(11), pp.1721-1728
Rusbridge, C., and Knowler, S.P. (2004) Inheritance of occipital bone hypoplasia (Chiari type I malformation) in Cavalier King Charles Spaniels. Journal of Veterinary Internal Medicine 18(5), pp.673-678 http://dx.doi.org/10.1111/j.1939-1676.2004.tb02605.x
Rusbridge, C., et al. (2015) International Veterinary Epilepsy Task Force recommendations for a veterinary epilepsy-specific MRI protocol. BMC veterinary research, 11:194 http://dx.doi.org/10.1186/s12917-015-0466-x
Seppälä, E.H., et al (2012) Identification of a novel idiopathic epilepsy locus in Belgian Shepherd dogs. PLoS One, 7(3): e33549 http://dx.doi.org/10.1371/journal.pone.0033549
Smith, P.M., Talbot, C.E. and Jeffery, N.D. (2008) Findings on low-field cranial MR images in epileptic dogs that lack interictal neurological deficits. The Veterinary journal, 176(3), pp. 320-325 http://dx.doi.org/10.1016/j.tvjl.2007.03.003
Srenk, P., et al. (1994) Genetic background for idiopathic epilepsy in Golden Retrievers. Tierarztliche Praxis, 22(6), pp.574-578
Srenk, P. and Jaggy, A. (1996) Interictal electroencephalographic findings in a family of Golden Retrievers with idiopathic epilepsy. Journal of Small Animal Practice 37(7), pp.317-321 http://dx.doi.org/10.1111/j.1748-5827.1996.tb02398.x
Van Meervenne, S.A E. et al. (2015) Association between Estrus and Onset of Seizures in Dogs with Idiopathic Epilepsy. Journal of Veterinary Internal Medicine 29(1) pp 251-263 http://dx.doi.org/10.1111/jvim.12505
Van Meervenne, S. A. E. et al (2014) The influence of sex hormones on seizures in dogs and humans. The Veterinary Journal, 201(1), pp.15–20 http://dx.doi.org/10.1016/j.tvjl.2014.05.008
Viitmaa, R., et al . (2006) Magnetic resonance imaging findings in Finnish spitz dogs with focal epilepsy. Journal of Veterinary Internal Medicine 20(2), pp. 305-310 http://dx.doi.org/10.1111/j.1939-1676.2006.tb02861.x
Viitmaa, R., et al (2013). Phenotype, inheritance characteristics, and risk factors for idiopathic epilepsy in Finnish Spitz dogs. Journal of the American Veterinary Medical Association, 243(7), 1001-1009 http://dx.doi.org/10.2460/javma.243.7.1001
Viitmaa, R., et al (2014) Cerebral glucose utilization measured with high resolution positron emission tomography in epileptic Finnish spitz dogs and healthy dogs. Veterinary Radiology & Ultrasound, 55(4), pp.453-461 http://dx.doi.org/10.1111/vru.12147
Weber, J., Maiolini, A. and Tipold, A. (2012) Evaluation of decreased glucose levels in the cerebrospinal fluid of dogs. Tierarztliche Praxis Kleintiere, 40(5) p325-332
Wessmann, A., et al (2010) Significance of surface epithelial cells in canine cerebrospinal fluid and relationship to central nervous system disease. Veterinary Clinical Pathology, 39(3), pp.358-364 http://dx.doi.org/10.1111/j.1939-165X.2010.00248.x
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