DOI
https://doi.org/10.18849/ve.v11i2.738Abstract
PICO Question
In dogs undergoing brachycephalic airway obstruction syndrome (BOAS) surgery does intraoperative constant rate infusion (CRI) of metoclopramide reduce the risk of regurgitation in the perioperative period?
Clinical bottom line
Category of research
Treatment.
Number and type of study designs reviewed
There were no publications that directly answered the PICO question. Two studies were identified which combined the use of metoclopramide in combination with other measures to reduce perioperative regurgitation.
Strength of evidence
Zero.
Outcomes reported
There is no data that solely assesses the effect of metoclopramide on gastro-oesophageal reflux in brachycephalic patients undergoing airway surgery.
Conclusion
Given the lack of evidence relating to the PICO question, the decision to use metoclopramide is based on personal preference and experience. Other medications and anaesthetic protocols that have been shown to reduce perioperative regurgitation should be considered first.
References
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Costa, R.S., Abelson, A.L., Lindsey, J.C. & Wetmore, L.A. (2020). Postoperative regurgitation and respiratory complications in brachycephalic dogs undergoing airway surgery before and after implementation of a standardized perianesthetic protocol. Journal of the American Veterinary Medical Association. 256(8), 899–905. DOI: https://doi.org/10.2460/javma.256.8.899
Favarato, E.S., Souza, M.Z., Costa, P.R.S., Favarato, L.S.C., Nehme, R.C., Monteiro, B.S. & Bonfá. (2012). Evaluation of metoclopramide and ranitidine on the prevention of gastroesophageal reflux episodes in anesthetized dogs. Research in Veterinary Science. 93(1), 466–467. DOI: https://doi.org/10.1016/j.rvsc.2011.07.027
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Wilson, D.V., Evans, A.T. & Mauer, W. (2005a). Effect of metoclopramide on gastro-esophageal reflux in anesthetized dogs. Veterinary Anaesthesia and Analgesia. 32(4), 4. DOI: https://doi.org/10.1111/j.1-2995.2005.00232a_8.x
Wilson, D.V., Evans, A.T. & Miller, R. (2005b). Effects of preanesthetic administration of morphine on gastroesophageal reflux and regurgitation during anesthesia in dogs. American Journal of Veterinary Research. 66(3), 386–390. DOI: https://doi.org/10.2460/ajvr.2005.66.386
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