In dogs undergoing anaesthesia do pre-anaesthetic gastroprotectants reduce gastro-oesophageal reflux?
Clinical bottom line
Category of research question
The number and type of study designs reviewed
Five papers were critically reviewed. There was a randomised prospective study, two randomised blinded prospective studies, randomised non-blinded prospective study and a randomised, double blinded and placebo-controlled prospective study.
Strength of evidence
Evidence of high quality suggests omeprazole or cisapride with esomeprazole decrease the incidence of gastro-oesophageal reflux (GOR) in the anaesthetised dog. In addition, a study of lower quality showed that continuous infusion of metoclopramide at a higher than normal dose rate decreased the incidence of GOR.
Omeprazole or cisapride with esomeprazole decreases the incidence of GOR in the anaesthetised dog.
The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.
Knowledge Summaries are a resource to help reinforce or inform decision-making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care
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Favarato, L. S. C., Favarato, E. S., Souza, M. V., Costa, P. R. S., Nehme, R. C., Monteiro, B. S. & Bonfá, L. P. (2012). Evaluation of metoclopramide and ranitidine on the prevention of gastroesophageal reflux episodes in anesthetized dogs. Research in Veterinary Science, 93(1), 466–467. DOI: https://doi.org/10.1016/j.rvsc.2011.07.027
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Rodríguez-Alarcón, C., Beristain-Ruiz, D., Rivera-Barreno, R., Díaz, G., Usón-Casaús, J., García-Herrera, R., Pérez-Merino, E., Universidad Autónoma de Ciudad Juárez & Universidad de Extremadura. (2015). Gastroesophageal reflux in anesthetized dogs: a review. Revista Colombiana de Ciencias Pecuaria, 28(2), 144–155. DOI: https://doi.org/10.17533/udea.rccp.v28n2a03
Wilson, D., Evans, A. & Mauer, W. (2006). Influence of metoclopramide on gastro-esophageal reflux in anesthetized dogs. American Journal of Veterinary Research, 67(1), 26–31. DOI: https://doi.org/10.2460/ajvr.67.1.26
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Zacuto, A. C., Marks, S. L., Osborn, J., Douthitt, K. L., Hollingshead, K. L., Hayashi, K., Kapatkin, A. S., Pypendop, B. H. & Belafsky, P. C. (2012). The Influence of Esomeprazole and Cisapride on Gastroesophageal Reflux During Anesthesia in Dogs. Journal of Veterinary Internal Medicine, 26(3), 518–525. DOI: https://doi.org/10.1111/j.1939-1676.2012.00929.x
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