DOI
https://doi.org/10.18849/ve.v8i4.623Abstract
PICO Question
Are felinised anti-nerve growth factor monoclonal antibodies (frunevetmab) effective at reducing the clinical signs of pain and immobility in cats with degenerative joint disease when compared with no treatment?
Clinical bottom line
Category of research
Treatment.
Number and type of study designs reviewed
Three peer-reviewed randomised controlled trial treatment studies, two of which were pilot studies.
Strength of evidence
Moderate.
Outcomes reported
All three studies concluded that there was a statistical reduction in pain and an improvement in mobility in the groups administered frunevetmab, when compared to the groups administered the placebo.
Conclusion
There is moderate evidence suggesting that the administration of frunevetmab by injection led to a reduction in pain and an increase in mobility. Injections were given at day 0; day 0 and 28, or day 0, 28 and 56 depending on the study. Further research should be conducted to ensure repeatability, involving more objectively measured outcomes to reduce the reliance on subjective measures which are more likely to have associated bias.
How to apply this evidence in practice
The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.
Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.
References
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Gruen, M.E., Griffith, E.H., Thomson, A.E., Simpson, W. & Lascelles, B.D.X. (2015). Criterion Validation Testing of Clinical Metrology Instruments for Measuring Degenerative Joint Disease Associated Mobility Impairment in Cats. PLOS ONE. 10(7), p.e0131839. DOI: https://doi.org/10.1371/journal.pone.0131839
Gruen, M.E., Thomson, A.E., Griffith, E..H, Paradise, H., Gearing, D.P. & Lascelles, B.D.X. (2016). A Feline‐Specific Anti‐Nerve Growth Factor Antibody Improves Mobility in Cats with Degenerative Joint Disease-Associated Pain: A Pilot Proof of Concept Study. Journal of Veterinary Internal Medicine. 30(4), 1138–1148. DOI: https://doi.org/10.1111/jvim.13972
Gruen, M.E., Myers, J.A.E. & Lascelles, B.D.X. (2021)a. Efficacy and Safety of an Anti-nerve Growth Factor Antibody (Frunevetmab) for the Treatment of Degenerative Joint Disease-Associated Chronic Pain in Cats: A Multisite Pilot Field Study. Frontiers in Veterinary Science, 8(610028). DOI: https://doi.org/10.3389/fvets.2021.610028
Gruen, M.E., Myers, J.A.E., Tena, J.S., Becskei, C., Cleaver, D.M. & Lascelles, B.D.X. (2021)b. Frunevetmab, a felinized anti-nerve growth factor monoclonal antibody, for the treatment of pain from osteoarthritis in cats. Journal of Veterinary Internal medicine. 35(6), 2752–2762. DOI: https://doi.org/10.1111/jvim.16291
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