Knowledge Summary image

Which is More Effective in Altering the Intra-Gastric pH in Dogs, Omeprazole or Ranitidine?

Adam Swallow

Published:  05/05/2016    in:  Knowledge Summaries
Views
2097
HTML:
1311
PDF:
707



Knowledge Summary image
Abstract

Clinical bottom line

Based on the current available evidence, omeprazole is the superior choice for raising intra-gastric pH.


Open AccessPeer Reviewed
Full Text:

HTML PDF


Click to see References Click to hide References
References

  1. Bersenas, A.M.E. et al. (2005) Effects of ranitidine, famotidine, pantoprazole, and omeprazole on intragastric pH in dogs. American Journal of Veterinary Research, 66 (3), pp. 425-431 http://dx.doi.org/10.2460/ajvr.2005.66.425    
  2. Fallenius, E. et al. (1981) Substituted benzimidazoles inhibit gastric secretion by blocking H+/ K+- ATPase. Nature 29:159- 161 http://dx.doi.org/10.1038/290159a0 
  3. Fallenius, E. et al. (1982) Inhibition of acid secretion in isolated gastric glands by substituted benzimidazoles. American Journal of Physiology 243: G505- G510. 
  4. Katz, L.B.Tobia, A.J. and Shriver, D.A. (1987) Effects of ORF 17583, other histamine H2-receptor antagonists and omeprazole on gastric acid secretory states in rats and dogs. Journal of Pharmacology and Experimental Therapeutics, 242 (2), pp. 437-42.
  5. Kromer, W. Postius, S. and Riedel, R. (2000) Animal Pharmacology of Reversible Antagonism of the Gastric Acid Pump, Compared to Standard Antisecretory Principles. Pharmacology, 60 (4), pp. 170-187 http://dx.doi.org/10.1159/000028367 
  6. Okabe, S. Shimosako, K. and Amagase, K. (2001) Pharmacological regulation of gastric acid secretion in the apical membrane of parietal cells; a new target for antisecretory drugs. Journal of Physiology and Pharmacology, 52 (4 Pt 1) pp. 639-56.
  7. Polentarutti, B. et al. (2010) Modification of gastric pH in the fasted dog. Journal of Pharmacy and Pharmacology, 62 (4), 462-469 http://dx.doi.org/10.1211/jpp.62.04.0008 
  8. Stachura, J. et al. (1983) Comparison of the effect of omeprazole--a substituted benzimidazole--and ranitidine--a potent H2-receptor antagonist--on histamine-induced gastric acid secretion and the ultrastructure of canine parietal cells. Hepatogastroenterology, 30 (5), pp. 205-10.


Refbacks
  • There are currently no refbacks.


Copyright (c) 2016 Adam Swallow

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Made possible through a project grant from the RCVS Council.

RCVS