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Which is More Effective in Altering the Intra-Gastric pH in Dogs, Omeprazole or Ranitidine?
Published: 05/05/2016 in: Knowledge Summaries
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Abstract
Clinical bottom line
Based on the current available evidence, omeprazole is the superior choice for raising intra-gastric pH.
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References
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- Polentarutti, B. et al. (2010) Modification of gastric pH in the fasted dog. Journal of Pharmacy and Pharmacology, 62 (4), 462-469 http://dx.doi.org/10.1211/jpp.62.04.0008
- Stachura, J. et al. (1983) Comparison of the effect of omeprazole--a substituted benzimidazole--and ranitidine--a potent H2-receptor antagonist--on histamine-induced gastric acid secretion and the ultrastructure of canine parietal cells. Hepatogastroenterology, 30 (5), pp. 205-10.
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