Do Palliative Steroids Prolong Survival in Dogs With Multicentric Lymphoma?



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PICO question

In dogs with naturally occurring multicentric B cell lymphoma does treatment with glucocorticoids alone extend survival time when compared to no treatment?

Clinical bottom line 

There is weak evidence, due to insufficient studies with untreated control groups, regarding the impact on survival of prednisolone treatment in dogs with multicentric lymphoma.

From the papers identified from the search functions used for the clinical question remission in uncontrolled trials was reported following prednisolone treatment. Details of which can be found in other sections of this paper.

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Squire, R., Bush, M., Melby, E. et al. (1973) Clinical and pathological study of canine lymphoma: clinical staging, cell classification and therapy. Journal of the National Cancer Institute, 51 (2), 565-74

Tozon, N., Samardzija, P., Prijic, S. et al (2006) Canine lymphoma: cytologic study and response to therapy. Slovenian Veterinary Research 43 (3) 127-133

Valli, V., Kass P., San Myint, M. et al. (2013) Canine lymphomas: association of classification type, disease stage, tumor type, disease stage, tumor subtype, mitotic rate, and treatment with survival. Domestic Mammal Disease 50 (5) 738-748 DOI:





Vol. 3 No. 1 (2018): The first issue of 2018

Section: Knowledge Summaries

Categories :  Small Animal  /  Dogs  /  Cats  /  Rabbits  /  Production Animal  /  Cattle  /  Sheep  /  Pig  /  Equine  /  Exotics  /