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Is the Use of Hypertonic Saline Effective in Reducing Intracranial Pressure After Traumatic Brain Injury in Dogs?

Alex Tischer, Ava Firth

Published:  15/05/2017    in:  Knowledge Summaries
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IV fluid bag
Abstract

Clinical bottom line:

Hypertonic saline appears to be effective in reducing intracranial pressure after traumatic brain injury in dogs in experimental studies.

 


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References

  1. Gunnar, W. et al. (1988) Head injury and hemorrhagic shock: studies of the blood brain barrier and intracranial pressure after resuscitation with normal saline solution, 3% saline solution, and dextran-40. Surgery, 103 (4), pp. 398–407.
  2. Gunnar, W. Kane, J. & Barrett, J. (1989) Cerebral blood flow following hypertonic saline resuscitation in an experimental model of hemorrhagic shock and head injury. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas / Sociedade Brasileira de Biofisica ... [et al.], 22 (2), pp. 287–289.
  3. Pinto, F.C.G. et al. (2015) Effect of volume replacement during combined experimental hemorrhagic shock and traumatic brain injury in prostanoids, brain pathology and pupil status. Arquivos de neuro-psiquiatria, 73 (6), pp. 499–505. http://dx.doi.org/10.1590/0004-282X20150039
  4. Pinto, F.C.G. et al. (2006) Volume replacement with lactated Ringer's or 3% hypertonic saline solution during combined experimental hemorrhagic shock and traumatic brain injury. The Journal of trauma, 60(4), pp. 758–63– discussion 763–4. 10.1097/01.ta.0000214581.89316.73
  5. Prough, D.S. JOHNSON, J.C. & Poole, G.V.J. (1986) Effects on intracranial pressure of resuscitation from hemorrhagic shock with hypertonic saline versus lactated Ringer's solution. Journal of Trauma and Acute Care Surgery, 26 (1), p. 97.
  6. Sharma, D. & Holowaychuk, M.K. (2015) Retrospective evaluation of prognostic indicators in dogs with head trauma: 72 cases (January-March 2011). Journal of Veterinary Emergency and Critical Care, 25 (5), pp. 631–639. 10.1111/vec.12328


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