DOI
https://doi.org/10.18849/ve.v10i4.730Abstract
Question
In dogs with acute pancreatitis, does pre-pyloric enteral nutrition compared to total parenteral nutrition result in an improved survival rate?
Clinical bottom line
Category of research:
Treatment.
Number and type of study designs reviewed:
One paper was critically reviewed. It was an open-label, prospective pilot study.
Strength of evidence:
Weak.
Outcomes reported:
There was no difference in outcome between the two treatments in this study.
Conclusion:
There is currently weak evidence on the effect of pre-pyloric enteral nutrition compared to total parenteral nutrition on the survival rate of dogs with acute pancreatitis.
References
Boreham, B. & Ammori, B.J. (2003). A prospective evaluation of pancreatic exocrine function in patients with acute pancreatitis: Correlation with extent of necrosis and pancreatic endocrine insufficiency. Pancreatology. 3(4), 303–308. DOI: https://doi.org/10.1159/000071768
Chan, D.L., Freeman, L.M., Labato, M.A. & Rush, J.E. (2002). Retrospective Evaluation of Partial Parenteral Nutrition in Dogs and Cats. Journal of Veterinary Internal Medicine. 16(4), 440–445. DOI: https://doi.org/10.1111/j.1939-1676.2002.tb01262.x
Chang, Y-s., Fu, H-q., Xiao, Y-m. & Liu, J-c. (2013). Nasogastric or nasojejunal feeding in predicted severe acute pancreatitis: a meta-analysis. Critical Care. 17(3), R118. DOI: https://doi.org/10.1186/cc12790
Eatock, F.C., Chong, P., Menezes, N., Murray, L., McKay, C.J., Carter, C.R. & Imrie, C.W. (2005). A Randomized Study of Early Nasogastric versus Nasojejunal Feeding in Severe Acute Pancreatitis. The American Journal of Gastroenterology. 100(2), 432–439. DOI: https://doi.org/10.1111/j.1572-0241.2005.40587.x
Flint, R.S. & Windsor, J.A. (2003). The role of the intestine in the pathophysiology and management of severe acute pancreatitis. HPB. 5(2), 69–85. DOI: https://doi.org/10.1080/13651820310001108
Freeman, L.M., Labato, M.A., Rush, J.E. & Murtaugh, R.J. (1995). Nutritional Support In Pancreatitis: A Retrospective Study. Journal of Veterinary Emergency and Critical Care. 5(1), 32–41. DOI: https://doi.org/10.1111/j.1476-4431.1995.tb00025.x
Heuter, K. (2004). Placement of jejunal feeding tubes for post-gastric feeding. Clinical Techniques in Small Animal Practice. 19(1), 32–42. DOI: https://doi.org/10.1053/S1096-2867(03)00082-3
Hinden, S.E. Schweighauser, A. & Francey, T. (2020). Evaluation of a novel non-surgical post-pyloric feeding technique in dogs with severe acute kidney injury. Journal of Veterinary Emergency and Critical Care. 30(4), 384–395. DOI: https://doi.org/10.1111/vec.12955
Jensen, K.B. & Chan, D.L. (2014). Nutritional management of acute pancreatitis in dogs and cats. Journal of Veterinary Emergency and Critical Care. 24(3), 240–250. DOI: https://doi.org/10.1111/vec.12180
Kumar, A., Singh, N., Prakash, S., Saraya, A., & Joshi, Y.K. (2006). Early Enteral Nutrition in Severe Acute Pancreatitis: A Prospective Randomized Controlled Trial Comparing Nasojejunal and Nasogastric Routes. Journal of Clinical Gastroenterology. 40(5), 431–434. DOI: https://doi.org/10.1097/00004836-200605000-00013
Lim, S.Y., Cridge, H., Twedt, D.C., Ohta, H., Nuruki, T., & Steiner, J.M. (2024). Management of acute-onset pancreatitis in dogs: a Narrative Review. Journal of the American Veterinary Medical Association. 262(9), 1231–1240. https://doi.org/10.2460/javma.24.02.0107
Mansfield, C. (2012). Acute Pancreatitis in Dogs: Advances in Understanding, Diagnostics, and Treatment. Topics in Companion Animal Medicine. 27(3), 123–132. DOI: https://doi.org/10.1053/j.tcam.2012.04.003
Mansfield, C. & Beths, T. (2015). Management of acute pancreatitis in dogs: a critical appraisal with focus on feeding and analgesia. Journal of Small Animal Practice. 56(1), 27–39. DOI: https://doi.org/10.1111/jsap.12296
Mansfield, C.S., James, F.E., Steiner, J.M., Suchodolski, J.S., Robertson, I.D. & Hosgood, G. (2011). A Pilot Study to Assess Tolerability of Early Enteral Nutrition via Esophagostomy Tube Feeding in Dogs with Severe Acute Pancreatitis. Journal of Veterinary Internal Medicine. 25(3), 419–425. DOI: https://doi.org/10.1111/j.1939-1676.2011.0703.x
Niederau, C., Niederau, M., Lüthen, R., Strohmeyer, G., Ferrell, L.D. & Grendell, J.H. (1990). Pancreatic exocrine secretion in acute experimental pancreatitis. Gastroenterology. 99(4), 1120–1127. DOI: https://doi.org/10.1016/0016-5085(90)90633-C
O’Keefe, S.J.D., Lee, R.B., Li, J., Stevens, S., Abou-Assi, S. & Zhou, W. (2005). Trypsin secretion and turnover in patients with acute pancreatitis. American Journal of Physiology-Gastrointestinal and Liver Physiology. 289(2), G181–G187. DOI: https://doi.org/10.1152/ajpgi.00297.2004
Qin, H.-L., Su, Z.-D., Hu, L.-G., Ding, Z.-X. & Lin, Q.-T. (2002). Effect of early intrajejunal nutrition on pancreatic pathological features and gut barrier function in dogs with acute pancreatitis. Clinical Nutrition. 21(6), 469–473. DOI: https://doi.org/10.1054/clnu.2002.0574
Qin, H.-L., Su, Z.-D., Hu, L.-G., Ding, Z.-X., & Lin, Q.-T. (2003). Parenteral versus early intrajejunal nutrition: Effect on pancreatitic natural course, entero-hormones release and its efficacy on dogs with acute pancreatitis. World Journal of Gastroenterology. 9(10), 2270–2273. DOI: http://dx.doi.org/10.3748/wjg.v9.i10.2270
Reuter, J.D., Marks, S.L., Rogers, Q.R., & Farver, T.B. (1998). Use of Total Parenteral Nutrition in Dogs: 209 Cases (1988-1995). Journal of Veterinary Emergency and Critical Care. 8(3), 201–213. DOI: https://doi.org/10.1111/j.1476-4431.1998.tb00126.x
Sax, H.C., Wamer, B.W., Talamini, M.A., Hamilton, F.N., Bell, R.H., Fischer, J.E. & Bower, R.H. (1987). Early total parenteral beneficial effects nutrition in acute pancreatitis: Lack of beneficial effects. The American Journal of Surgery. 153(1), 117–124. DOI: https://doi.org/10.1016/0002-9610(87)90211-x
Simpson, K. & Lamb, C. (1995). Acute pancreatitis in the dog. In Practice. 17(7), 328–337. DOI: https://doi.org/10.1136/inpract.17.7.328
Stabile, B.E., Borzatta, M. & Stubbs, R.S. (1984). Pancreatic Secretory Responses to Intravenous Hyperalimentation and Intraduodenal Elemental and Full Liquid Diets. Journal of Parenteral and Enteral Nutrition. 8(4), 377–380. DOI: https://doi.org/10.1177/0148607184008004377
Thomson, A. (2006). Nutrition Therapy in Acute Pancreatitis. Journal of Parenteral and Enteral Nutrition. 30(6), 536–537. DOI: https://doi.org/10.1177/0148607106030006536
Williams, D.A. (1994). Diagnosis and management of pancreatitis. Journal of Small Animal Practice. 35(9), 445–454. DOI: https://doi.org/10.1111/j.1748-5827.1994.tb03945.x
Xu, G.-f., Zheng, L., Jun, G., Li, Z.-s. & Gong, Y.-f. (2006). Effect of ecoimmunonutrition supports on maintenance of integrity of intestinal mucosal barrier in severe acute pancreatitis in dogs. Chinese Medical Journal. 119(8), 656–662.
License
Copyright (c) 2025 Felix Tsz Fung Ting
This work is licensed under a Creative Commons Attribution 4.0 International License.
Veterinary Evidence uses the Creative Commons copyright Creative Commons Attribution 4.0 International License. That means users are free to copy and redistribute the material in any medium or format. Remix, transform, and build upon the material for any purpose, even commercially - with the appropriate citation.
