DOI
https://doi.org/10.18849/ve.v10i4.720Abstract
Question
In dogs, does undergoing a tibial plateau levelling osteotomy (TPLO) compared to not undergoing a TPLO affect the future risk of developing osteosarcoma?
Clinical bottom line
Category of research:
Risk.
Number and type of study designs reviewed:
One experimental study, designed as a matched case control.
Strength of evidence:
Weak.
Outcomes reported:
Only one study is appropriately designed to investigate a TPLO and associated osteosarcoma risk. This study found a 40-fold increased risk in dogs with a history of TPLO, compared to dogs that had not undergone a TPLO (OR, 40.65; 95% CI, 4.04 to 409.06; P = 0.002).
Conclusion:
There is weak yet preliminary indication to suggest a TPLO increases a dog’s risk of developing osteosarcoma later in life. However, with such a wide confidence interval, the true effect remains unclear. Additional matched case-control studies are needed to strengthen knowledge of this correlation, however until this time osteosarcoma should be considered as a differential diagnosis in post-TPLO dogs which present with lameness and/or proximal limb swelling.
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