DOI
https://doi.org/10.18849/ve.v9i4.691Abstract
Question
In cats with osteoarthritis (OA), does the oral supplementation of cannabidiol (CBD) oil, compared to conventional treatment alone, improve treatment outcomes of reducing pain and improving locomotion?
Clinical bottom line
The category of research question was:
Treatment.
The number and type of study designs that were critically appraised were:
No papers were found relevant to the PICO.
Critical appraisal of the selected papers meeting the inclusion criteria collectively provide zero/weak/moderate/strong evidence in terms of their experimental design and implementation:
Zero.
The outcomes reported are summarised as follows…
No studies relevant to the PICO were found (in English) on the use of CBD in cats with OA.
In view of the strength of evidence and the outcomes from the studies the following conclusion is made…
There is currently no evidence to recommend the use of CBD in cats for the treatment of OA and further studies on therapeutic use of CBD in cats with OA are required.
References
Gamble, L.-J., Boesch, J.M., Frye, C.W., Schwark, W.S., Mann, S., Wolfe, L., Brown, Holly., Berthelsen, E.S. & Wakshlag, J.J. (2018). Pharmacokinetics, safety, and clinical efficacy of cannabidiol treatment in osteoarthritic dogs. Frontiers in Veterinary Evidence. 5, 165. DOI: https://doi.org/10.3389/fvets.2018.00165
Gutierre, E., Crosignani, N., García-Carnelli, C., di Mateo., A. & Recchi, L. (2023). A case report of CBD and THC as analgesic therapy in a cat with chronic osteoarthritic pain. Veterinary Medicine and Science. 9(3), 1021–1025. DOI: https://doi.org/10.1002/vms3.1057
Kulpa, J.E., Paulionis, L.J., Eglit, G.M. & Vaughn, D.M. (2021). Safety and tolerability of escalating cannabinoid doses in healthy cats. Journal of Feline Medicine and Surgery. 23(12), 1162–1175. DOI: https://doi.org/10.1177/1098612X211004215
Mejia, S. Duerr, F.M.D., Griffenhagen, G. & McGrath, S. (2021). Evaluation of the effect of cannabidiol on naturally occurring osteoarthritis-associated pain: A pilot study in dogs. Journal of the American Animal Hospital Association. 57(2), 81–90. DOI: https://doi.org/10.5326/jaaha-ms-7119
Milevoj, N., Tozon, N. & Tomsič, K. (2022). Use of cannabidiol products by pet owners in Slovenia: A survey-based study. Slovenian Veterinary Research. 59(3), 149–158 DOI: https://doi.org/10.26873/SVR-1294-2022
Patikorn, C. Nerapusee, O., Soontornvipart, K., Musipodok, K., Waleethanaphan, K. & Anantachoti., P. (2023). Efficacy and safety of cannabidiol for the treatment of canine osteoarthritis: a systematic review and meta-analysis of animal intervention studies. Frontiers in Veterinary Science. 10, 1248417. DOI: https://doi.org/10.3389/fvets.2023.1248417
Verrico, C.D. Wesson, S., Konduri, V., Hofferek, C.J., Vazquez-Perez, J., Blair, E., Dunner, K.Jr., Salimpour, P., Decker, W.K. & Halpert, M.M. (2020). A randomized, double-blind, placebo-controlled study of daily cannabidiol for the treatment of canine osteoarthritis pain. Pain. 161(9), 2191–2202. DOI: https://doi.org/10.1097/j.pain.0000000000001896
Wang, T., Zakharov, A., Gomez, B., Lyubimov., A Trottier, N.L., Schwark, W.S. & Wakshlag, J.J. (2022). Serum Cannabinoid 24 h and 1 Week Steady State Pharmacokinetic Assessment in Cats Using a CBD/CBDA Rich Hemp Paste. Frontiers in Veterinary Science. 9, 895368. DOI: https://doi.org/10.3389/fvets.2022.895368
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