DOI
https://doi.org/10.18849/ve.v9i1.679Abstract
PICO Question
In dogs with anxious behaviours, is fluoxetine more effective than clomipramine in reducing anxiety-related behaviours?
Clinical bottom line
Category of research
Treatment.
Number and type of study designs reviewed
Three controlled studies were critically appraised.
Strength of evidence
Moderate.
Outcomes reported
Administration of either fluoxetine or clomipramine to adult dogs reduces symptoms of fear and anxiety.
Conclusion
Both fluoxetine and clomipramine are effective in reducing acral lick dermatitis and tail chasing behaviours, but there is no evidence that one drug is more effective than the other.
How to apply this evidence in practice
The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.
Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.
References
Rapoport, J.L., Ryland, D.H. & Kriete, M. (1992). Drug Treatment of Canine Acral Lick. An Animal Model of Obsessive-compulsive Disorder. Archives of General Psychiatry. 49(7), 517–521. DOI: https://doi.org/10.1001/archpsyc.1992.01820070011002
Unnithan, P., Maheshkrishna, Nagarajan, B., Kavitha, S. & Nambi, A.P. (2021). A Comparison on Therapeutic Efficacy of Fluoxetine and Clomipramine in Treatment of Canine Acral Lick Dermatitis. Indian Veterinary Journal. 98(01), 32–33.
Yalcin, E. (2010). Comparison of clomipramine and fluoxetine treatment of dogs with tail chasing. Tierärztliche Praxis. Ausgabe K:, Kleintiere / Heimtiere. 38(5), 295–299.
License
Copyright (c) 2024 Olivia Williamson, Valery Varela, Christopher Minami, Juliana Tom, Elizabeth Powell, Jeffrey W. Norris
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