Comparing the effectiveness of clomipramine and fluoxetine in dogs with anxiety-related behaviours



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PICO Question

In dogs with anxious behaviours, is fluoxetine more effective than clomipramine in reducing anxiety-related behaviours?


Clinical bottom line

Category of research


Number and type of study designs reviewed

Three controlled studies were critically appraised.

Strength of evidence


Outcomes reported

Administration of either fluoxetine or clomipramine to adult dogs reduces symptoms of fear and anxiety.


Both fluoxetine and clomipramine are effective in reducing acral lick dermatitis and tail chasing behaviours, but there is no evidence that one drug is more effective than the other.


How to apply this evidence in practice

The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.

Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.


Rapoport, J.L., Ryland, D.H. & Kriete, M. (1992). Drug Treatment of Canine Acral Lick. An Animal Model of Obsessive-compulsive Disorder. Archives of General Psychiatry. 49(7), 517–521. DOI:

Unnithan, P., Maheshkrishna, Nagarajan, B., Kavitha, S. & Nambi, A.P. (2021). A Comparison on Therapeutic Efficacy of Fluoxetine and Clomipramine in Treatment of Canine Acral Lick Dermatitis. Indian Veterinary Journal. 98(01), 32–33.

Yalcin, E. (2010). Comparison of clomipramine and fluoxetine treatment of dogs with tail chasing. Tierärztliche Praxis. Ausgabe K:, Kleintiere / Heimtiere. 38(5), 295–299.

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Vol. 9 No. 1 (2024): The first issue of 2024

Section: Knowledge Summaries

Categories :  Small Animal  /  Dogs  /  Cats  /  Rabbits  /  Production Animal  /  Cattle  /  Sheep  /  Pig  /  Equine  /  Exotics  /