In rabbits with cheyletiellosis is topical selamectin or injectable ivermectin a more effective treatment?



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PICO question

In rabbits with cheyletiellosis is topical selamectin or injectable ivermectin a more effective treatment?


Clinical bottom line

Category of research


Number and type of study designs reviewed

One paper directly answered the PICO question, a retrospective clinical design study, and was critically reviewed.

Strength of evidence.


Outcomes reported

Both topical selamectin and injectable ivermectin are safe and effective in treating cheyletiellosis. There is no significant difference in the effectiveness of both drugs in treating the infestation.


In pet rabbits with Cheyletiella parasitivorax infestations both topical selamectin and injectable ivermectin have been recognised to be a safe and effective treatment. There is currently insufficient evidence that one is more effective than the other and therefore veterinarians should consider their own clinical experience, client preference and use the licensed product first (in the UK, ivermectin (Xeno, Dechra) spot-on). However, this Knowledge Summary does not comment on the effectiveness of topical ivermectin in treating cheyletiellosis. If injectable ivermectin is , topical selamectin can be used under the cascade as an alternative treatment, as it is licensed for the same indication in dogs and cats.

How to apply this evidence in practice

The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.

Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.


Coşkunserçe, G., Akdeşir, E., Kaya, G. & Coşkun, Ş. (2012). Severe sarcoptic mange and cheyletiellosis in a New Zealand rabbit and its treatment with high dosage of ivermectin. Veteriner Fakültesi Dergisi, Uludağ Üniversitesi. [online]. 31(2), 63–66. Available at: [Accessed 18 Aug 2021].

Farmaki, R., Koutinas, A. F., Kasabalis, D., Papazahariadou, M. G. & Day, M. J. (2009). Efficacy of a selamectin spot-on formulation in rabbits with sarcoptic mange. Veterinary Record. 164(14), 431–439. DOI:

Kim, S., Lee, J., Jun, H., Song, K., Park, B. & Kim, D. (2008). Efficacy of selamectin in the treatment of cheyletiellosis in pet rabbits. Veterinary Dermatology. 19(1), 26–27. DOI:

Niaz, K. & Shoaib, M. (2015). Comparative Study of Ivermectin and Cypermethrin against Sarcoptes Scabiei in Rabbit. International Journal of Innovative Research and Development. 4(5).

Robinson N. & Brennan, M. (2016). Selamectin versus ivermectin for cheyletiellosis in pet rabbits. Veterinary Record. 178(14), 344-345. DOI:

Vol. 7 No. 4 (2022): The fourth issue of 2022

Section: Knowledge Summaries

Categories :  Small Animal  /  Dogs  /  Cats  /  Rabbits  /  Production Animal  /  Cattle  /  Sheep  /  Pig  /  Equine  /  Exotics  /