In auction market calves at high risk of developing bovine respiratory disease (BRD), does delayed (14–30 days) vaccination with a modified live vaccine (MLV) for viral respiratory pathogens versus administration of MLV on arrival (within 24 hours of arrival) to the stocker operation, result in less calves with BRD morbidity diagnosed based on visual signs and rectal temperature >40°C, or less calves with BRD mortality?
Clinical bottom line
Category of research question
The number and type of study designs reviewed
Four papers were critically reviewed. All were randomised complete block designs
Strength of evidence
In stocker calves, delaying administration of a MLV for respiratory viruses may result in numerically lower initial BRD morbidity rates, while giving at arrival may result in numerically lower BRD retreatments. One study shows statistically lower cases of BRD morbidity after the third antimicrobial treatment in cattle vaccinated on arrival with both a clostridial and MLV for respiratory viruses compared to cattle vaccinated on arrival with clostridial vaccine and delayed MLV for respiratory viruses. No conclusion about mortality can be drawn due to inconsistent numerical conclusions between studies
Due to conflicting evidence and a general lack of statistically significant differences in morbidity and mortality outcomes, a definite answer regarding the impact of delayed MLV respiratory vaccination in stocker calves cannot be made
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O’Connor, A.M., Hu, D., Totton, S.C., Scott, N., Winder, C.B., Wang, B., Wang, C., Glanville, J., Wood, H., White, B., Larson, R., Waldner, C. & Sargeant, J.M. (2019). A systematic review and network meta-analysis of injectable antibiotic options for the control of bovine respiratory disease in the first 45 days post arrival at the feedlot. Animal Health Research Reviews. 20, 163–181. DOI: https://doi.org/10.1017/S1466252320000031
Poe, K.D., Beck, P.A., Richeson, J.T., Gadberry, M.S., Kegley, E.B., Hess, T.W. & Hubbell, D.S. (2013). Effects of respiratory vaccination timing and growth-promoting implant on health, performance, and immunity of high-risk, newly received stocker cattle. Applied Animal Science. 29(4), 413–419. DOI: https://doi.org/10.15232/S1080-7446(15)30254-0
Richeson, J.T., Beck, P.A., Gadberry, M.S., Gunter, S.A., Hess, T.W., Hubbell, D.S. & Jones, C. (2008). Effects of on-arrival versus delayed modified live virus vaccination on health, performance, and serum infectious bovine rhinotracheitis titers of newly received beef calves. Journal of Animal Science. 84(4), 999–1005. DOI: https://doi.org/10.2527/jas.2007-0593
Richeson, J.T., Kegley, E.B., Gadberry, M.S., Beck, P.A., Powell, J.G. & Jones, C.A. (2009). Effects of on-arrival versus delayed clostridial or modified live respiratory vaccinations on health, performance, bovine viral diarrhea virus type I titers, and stress and immune measures of newly received beef calves. Journal of Animal Science. 87(7), 2409–2418. DOI: http://dx.doi.org/10.2527/jas.2008-1484
Richeson, J.T., Beck, P.A., Poe, K.D., Gadberry, M.S., Hess, T.W. & Hubbell, D.S. (2015). Effects of administration of a modified-live virus respiratory vaccine and timing of vaccination on health and performance of high-risk beef stocker calves. The Bovine Practitioner. 49(1), 37–42. DOI: https://doi.org/10.21423/bovine-vol49no1p37-42
Roberts, S.L., Powell, J.G., Hughes, H.D. & Richeson, J.T. (2018). Effect of castration method and analgesia on inflammation, behavior, growth performance, and carcass traits in feedlot cattle. Journal of Animal Science. 91(1), 66–75. DOI: https://doi.org/10.1093/jas/skx022
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