Can vaccinating sheep reduce the occurrence of caseous lymphadenitis?

  • Vitória Souza de Oliveira Nascimento 87 Prof. Orlando Marques de Paiva, Sao Paulo, SP. 05508-010, Brazil



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PICO question

Is there a decrease of caseous lymphadenitis in vaccinated sheep compared to unvaccinated sheep?

Clinical bottom line

The evidence provided by the studies used is strong (all have been randomised controlled trials), supporting the hypothesis that sheep vaccinated against caseous lymphadenitis (CLA) are less likely to develop the disease when compared to unvaccinated sheep. Vaccination may be a useful tool in the prevention and control of clinical CLA following a risk assessment.

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Eggleton, D.G., Doidge, C.V., Middleton, H.D., Minty, D.W. 1991.Immunisation against ovine caseous lymphadenitis: efficacy of monocomponent Corynebacterium pseudotuberculosis toxoid vaccine and combined clostridial-corynebacterial vaccines. Australian Veterinary Journal. 68(10): 320–321. DOI:

Eggleton, D.G., Middleton, H.D., Doidge, C.V., Minty, D.W. 1991. Immunisation against ovine caseous lymphadenitis: comparison of Corynebacterium pseudotuberculosis vaccines with and without bacterial cells. Australian Veterinary Journal 68(10): 317–319. DOI:

Eshra, M.A., Mahmoud, A.K.A., Elshemey, T.M., Abdurrahman, A.H. Abbas, O.M. Alexandria. 2018. A trial for vaccination of sheep against Caseous lymphadentitis using oil adjuvent bacterin enhance by Bacillus Calmette-Guerin vaccine. Journal of Veterinary Sciences; 2018. 57(1): 140–147. DOI:

Ghani, T.Y., Habasha, F.G. 2016. Caseous lymphadenitis in Iraqi sheep and assessment of vaccination with commercial vaccine. Basrah Journal of Veterinary Research 2016. 15(3): 532–541.

Izgur, M., Akan, M., Ilhan, Z., Yazcoglu, N. Studies on vaccine development for ovine caseous lymphadenitis. Universitesi Veteriner Fakultesi Dergisi 57(3): 161–165.

LeaMaster, B.R., Shen, D.T., Gorham, J.R., Leathers, C.W., Wells, H.D. 1987. Efficacy of Corynebacterium pseudotuberculosis bacterin for the immunologic protection of sheep against development of caseous lymphadenitis. American Journal of Veterinary Research 48(5): 869–872.

Menzies, P.I., Muckle, C.A., Brogden, K.A., Robinson, L. 1991. A field trial to evaluate a whole cell vaccine for the prevention of caseous lymphadenitis in sheep and goat flocks. Canadian Journal of Veterinary Research; 1991. 55(4): 362–366.

Paton, M.W., Sutherland, S.S., Rose, I.R., Hart, R.A., Mercy, A.R., Ellis, T.M. 1995. The spread of Corynebacterium pseudotuberculosis infection to unvaccinated and vaccinated sheep. Australian Veterinary Journal 72(7): 266–269. DOI:

Sohier, S.M., Abuelnaga, A.S.M., Ibrahim, E.S., Hakim, A.S. 2018. Evaluation of specific and non-specific immune response of four vaccines for caseous lymphadenitis in sheep challenged. Veterinary World; 2018. 11(9): 1272–1276. DOI:

Stanford, K. Brogden, K.A., McClelland, L.A., Kozub, G.C., Audibert, F. 1998. The incidence of caseous lymphadenitis in Alberta sheep and assessment of impact by vaccination with commercial and experimental vaccines. Canadian Journal of Veterinary Research 62(1): 38–43.





Vol. 5 No. 1 (2020): The first issue of 2020

Section: Knowledge Summaries

Categories :  Small Animal  /  Dogs  /  Cats  /  Rabbits  /  Production Animal  /  Cattle  /  Sheep  /  Pig  /  Equine  /  Exotics  /