There is no evidence that the addition of antimicrobials reduce the risk of sepsis after intra-articular corticosteroids in horses with arthritis

  • Elena Gogua Moscow state academy of veterinary medicine and biotechnology named K.I. Skryabin Academic Skryabin St., 23 Moscow, 109472



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PICO question

In horses with arthritis, does the treatment with intra-articular antimicrobials concurrently with intra-articular corticosteroids reduce the risk of sepsis compared to intra-articular corticosteroids alone?

Clinical bottom line

The three studies identified did not demonstrate a reduction of risk when antimicrobials were used. However, the strength of evidence provided by the studies was weak. The power of the studies to detect an effect of antimicrobials was low due to the small number of sepsis cases recorded. Further studies are therefore required to draw conclusions.

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Adams, S. B. (2012) How to avoid complications of intra-synovial injections II: selection of drugs, injection of drugs, and recognition and treatment of sepsis. Proceedings of the 58th Annual Convention of the American Association of Equine Practitioners, Anaheim, California, USA, 1-5 December 2012; 2012.:476-482.

Lapointe, J. M. Laverty, S. Lovoie, J. P. (1992) Septic arthritis in 15 Standardbred racehorses after intra-articular injection. Equine Veterinary Journal, 24(6):430-434.

Peremans, K. Verschooten, F. Moor, A. de Desmet, P. (1991) Monoarticular infectious arthritis in the horse: 34 cases. Journal of Equine Veterinary Science, 11(1):27-32.

Vol. 5 No. 1 (2020): The first issue of 2020

Section: Knowledge Summaries

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