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PICO question

In dogs with chronic enteropathy does treatment with oral cobalamin compared to parenteral cobalamin provide serum cobalamin levels greater than 270 ng/L?

Clinical bottom line

The evidence provided by block randomised controlled clinical trials indicates that oral dosing of cobalamin results in normocobalaminaemia, with levels similar to that achieved with parenteral dosing. These studies provide veterinary professionals with dosing schedules, and monitoring serum cobalamin levels is recommended to ensure normocobalaminaemia is achieved. It has been shown that supplementation with both oral and parenteral cobalamin correlates with increased intracellular cobalamin levels. Future studies are needed to investigate the outcome of oral cobalamin dosing in dogs with extra-gastrointestinal disease.


Open Access Peer Reviewed