In treatment of canine patients with meningoencephalitis of unknown origin (MUO), is combination therapy of cytosine arabinoside (CA) with prednisolone more effective than prednisolone as a sole therapy at increasing survival time?
Clinical bottom line
Based on current available evidence, cytosine arabinoside with prednisolone has greater median survival time than prednisolone as a sole therapy in dogs with meningoencephalitis of unknown origin. The evidence to support this is very weak, as there are currently a low number of published papers with a relatively small number of cases reported in these studies evaluating cytosine arabinoside with prednisolone or prednisolone as a sole therapy for treatment of meningoencephalitis of unknown origin.
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Lowrie, M., Thomson, S., Smith, P., et al, 2016. Effect of a constant rate infusion of cytosine arabinoside on mortality in dogs with meningoencephalitis of unknown origin. The Veterinary Journal, 213, pp.1-5. http://dx.doi.org/10.1016/j.tvjl.2016.03.026
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Zarfoss, M., Schatzberg, S., Venator, K., et al, 2006. Combined cytosine arabinoside and prednisone therapy for meningoencephalitis of unknown aetiology in 10 dogs. Journal of small animal practice, 47(10), pp.588-595.
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