Can Cytosine Arabinoside With Prednisolone Treatment for Canine Meningoencephalitis of Unknown Origin Increase Survival Time Compared to Prednisolone Treatment Alone?

  • Christopher Stefan Francis Kozlowski Hoey University of Bristol, Bristol Veterinary School, Langford House, Langford, Bristol BS40 5DU
  • Christina Maunder University of Bristol, Bristol Veterinary School, Langford House, Langford, Bristol BS40 5DU



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PICO question

In treatment of canine patients with meningoencephalitis of unknown origin (MUO), is combination therapy of cytosine arabinoside (CA) with prednisolone more effective than prednisolone as a sole therapy at increasing survival time?

Clinical bottom line

Based on current available evidence, cytosine arabinoside with prednisolone has greater median survival time than prednisolone as a sole therapy in dogs with meningoencephalitis of unknown origin. The evidence to support this is very weak, as there are currently a low number of published papers with a relatively small number of cases reported in these studies evaluating cytosine arabinoside with prednisolone or prednisolone as a sole therapy for treatment of meningoencephalitis of unknown origin.

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Lowrie, M., Thomson, S., Smith, P., et al, 2016. Effect of a constant rate infusion of cytosine arabinoside on mortality in dogs with meningoencephalitis of unknown origin. The Veterinary Journal, 213, pp.1-5.

Lowrie, M., Smith, P. and Garosi, L., 2013. Meningoencephalitis of unknown origin: investigation of prognostic factors and outcome using a standard treatment protocol. Vet Rec, 172(20), p.527.

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Smith, P., Stalin, C., Shaw, D., et al, 2009. Comparison of two regimens for the treatment of meningoencephalomyelitis of unknown etiology. Journal of veterinary internal medicine, 23(3), pp.520-526.

Zarfoss, M., Schatzberg, S., Venator, K., et al, 2006. Combined cytosine arabinoside and prednisone therapy for meningoencephalitis of unknown aetiology in 10 dogs. Journal of small animal practice, 47(10), pp.588-595.





Vol. 3 No. 3 (2018): The third issue of 2018

Section: Knowledge Summaries

Categories :  Small Animal  /  Dogs  /  Cats  /  Rabbits  /  Production Animal  /  Cattle  /  Sheep  /  Pig  /  Equine  /  Exotics  /