Does Adding Transdermal Nitroglycerine to Other Therapies Used for Management of Left-sided Congestive Heart Failure in Dogs Speed the Resolution of Clinical Signs?

  • Jenefer R Stillion Western Veterinary Specialist and Emergency Centre, Calgary, Canada
  • Søren R Boysen Department of Veterinary Clinical and Diagnostic Sciences, Faculty of Veterinary Medicine, University of Calgary, Calgary, Canada

Published:

2017-12-12

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DOI

https://doi.org/10.18849/ve.v2i4.115

Abstract

There is an erratum to this paper published in Veterinary Evidence Vol 3, Issue 1 (2018): http://dx.doi.org/10.18849/ve.v3i1.168

Clinical bottom line

There is very weak veterinary clinical and experimental evidence based upon a limited number of studies to indicate that adding transdermal nitroglycerine to other therapies used for management of left-sided congestive heart failure in dogs speeds the resolution of clinical signs.

 


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Author Biographies

Jenefer R Stillion, Western Veterinary Specialist and Emergency Centre, Calgary, Canada

Western Veterinary Specialist and Emergency Centre, Calgary, Canada

Søren R Boysen, Department of Veterinary Clinical and Diagnostic Sciences, Faculty of Veterinary Medicine, University of Calgary, Calgary, Canada

Professor, Veterinary Emergency and Crtical Care, Department of Veterinary Clinical and Diagnostic Sciences,
Faculty of Veterinary Medicine, University of Calgary

References

Kanda A, Yoshida M, Kanou M, et al. (1995). Cardiovascular effects of NT-1, a new patch form of nitroglycerin, alone and in combination with nifedipine in conscious dogs. Journal of Pharmacy Pharmacology. 47(12A): pp. 1021-1024. DOI: http://dx.doi.org/10.1111/j.2042-7158.1995.tb03289.x

McKie PM, Cataliotti A, Ichiki T, et al. (2014). M-atrial natriuretic peptide and nitroglycerin in a canine model of experimental acute hypertensive heart failure: differential actions of 2 cGMP activating therapeutics. Journal of the American Heart Association, 3(1):e000206. DOI: http://dx.doi.org/10.1161/JAHA.113.000206

Nakayama, T. Nishijima, Y.  Miyamoto, et al. (2007). Effects of 4 classes of cardiovascular drugs on ventricular function in dogs with mitral regurgitation.   Journal of Veterinary Internal Medicine, 21(3), pp. 445-450. PMID: 17552449 DOI: http://dx.doi.org/10.1111/j.1939-1676.2007.tb02988.x

Parameswaran, N. Hamlin, R. L.  Nakayama, T.  Rao, S. S. (1999). Increased splenic capacity in response to transdermal application of nitroglycerin in the dog.   Journal of Veterinary Internal Medicine, 13(1), pp. 44-46. PMID: 10052063 DOI: 1111/j.1939-1676.1999.tb02164.x

Sellers R, Levy M, Amplatz K, Lillehei CW. Left retrograde cardioangiography in  acquired  cardiac  disease:  Technic,  indications  and  interpretations  in  700    Am J  Cardiol  1964;14: 437–447 DOI: http://dx.doi.org/10.1016/0002-9149(64)90027-X

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Vol. 2 No. 4 (2017): The fourth issue of 2017

Section: Knowledge Summaries

Categories :  Small Animal  /  Dogs  /  Cats  /  Rabbits  /  Production Animal  /  Cattle  /  Sheep  /  Pig  /  Equine  /  Exotics  /