TY - JOUR AU - Williams, Savannah PY - 2022/12/07 Y2 - 2024/03/28 TI - Do inhaled or oral glucocorticoids more effectively control feline asthma? JF - Veterinary Evidence JA - VE VL - 7 IS - 4 SE - Knowledge Summaries DO - 10.18849/ve.v7i4.560 UR - https://veterinaryevidence.org/index.php/ve/article/view/560 SP - AB - <p><strong>PICO question</strong></p><p>In cats with chronic bronchospasm and airway hypersensitivity (asthma) do oral glucocorticoids or inhaled glucocorticoids more effectively control the clinical signs?</p><p>&nbsp;</p><p><strong>Clinical bottom line</strong></p><p><strong>Category of research question</strong></p><p>Treatment</p><p><strong>The number and type of study designs reviewed</strong></p><p>Three prospective randomised clinical trials were appraised. Two of the studies followed a crossover design and had a control group, whilst the third study described an interrupted time series</p><p><strong>Strength of evidence</strong></p><p>Weak</p><p><strong>Outcomes reported</strong></p><p>The available studies deemed a reduction in eosinophilia on bronchoalveolar lavage fluid analysis, and a reduction in airway resistance as markers of treatment efficacy</p><p><strong>Conclusion</strong></p><p>There is weak evidence to suggest equal treatment efficacy of oral and inhaled glucocorticoid therapy for management of feline asthma. Higher powered studies would be required before a definitive recommendation can be made</p><p>&nbsp;</p><p><span style="color: #0000ff;"><a style="color: #0000ff;" href="https://learn.rcvsknowledge.org/mod/book/view.php?id=50" target="_blank" rel="noopener">How to apply this evidence in practice</a></span></p><p>The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.</p><p>Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.</p> ER -