TY - JOUR AU - Barry, Leanne PY - 2020/11/12 Y2 - 2024/03/29 TI - In dogs undergoing anaesthesia do pre-anaesthetic gastroprotectants reduce gastro-oesophageal reflux? JF - Veterinary Evidence JA - VE VL - 5 IS - 4 SE - Knowledge Summaries DO - 10.18849/ve.v5i4.340 UR - https://veterinaryevidence.org/index.php/ve/article/view/340 SP - AB - <p><strong>PICO question</strong></p><p>In dogs undergoing anaesthesia do pre-anaesthetic gastroprotectants reduce gastro-oesophageal reflux?</p><p>&nbsp;</p><p><strong>Clinical bottom line</strong></p><p><strong>Category of research question</strong></p><p>Treatment</p><p><strong>The number and type of study designs reviewed</strong></p><p>Five papers were critically reviewed. There was a randomised prospective study, two randomised blinded prospective studies, randomised non-blinded prospective study and a randomised, double blinded and placebo-controlled prospective study.</p><p><strong>Strength of evidence</strong></p><p>Moderate</p><p><strong>Outcomes reported</strong></p><p>Evidence of high quality suggests omeprazole or cisapride with esomeprazole decrease the incidence of gastro-oesophageal reflux (GOR) in the anaesthetised dog. In addition, a study of lower quality showed that continuous infusion of metoclopramide at a higher than normal dose rate decreased the incidence of GOR.</p><p><strong>Conclusion</strong></p><p>Omeprazole or cisapride with esomeprazole decreases the incidence of GOR in the anaesthetised dog.</p><p>&nbsp;</p><p><span style="color: #0000ff;"><a style="color: #0000ff;" href="http://www.ebvmlearning.org/apply/" target="_blank" rel="noopener">How to apply this evidence in practice</a></span></p><p>The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.</p><p>Knowledge Summaries are a resource to help reinforce or inform decision-making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care</p><p>&nbsp;</p><p><img src="https://www.veterinaryevidence.org/rcvskmod/icons/oa-icon.jpg" alt="Open Access"> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/pr-icon.jpg" alt="Peer Reviewed"></p> ER -