TY - JOUR AU - Safrany, Ben AU - Adamantos, Sophie PY - 2020/05/06 Y2 - 2024/03/29 TI - Is a cross-match necessary before a cat’s first blood transfusion? JF - Veterinary Evidence JA - VE VL - 5 IS - 2 SE - Knowledge Summaries DO - 10.18849/ve.v5i2.306 UR - https://veterinaryevidence.org/index.php/ve/article/view/306 SP - AB - <p><strong>PICO question</strong></p><p>In transfusion-naïve cats receiving a type specific blood transfusion is cross-matched blood (major and minor) associated with an increased haematocrit development and reduction in acute transfusion reactions when compared with those receiving non-crossmatched blood?</p><p>&nbsp;</p><p><strong>Clinical bottom line</strong></p><p><strong>Category of research question </strong></p><p>Treatment</p><p><strong>The number and type of study designs reviewed</strong></p><p>Ten papers were critically reviewed. There were four retrospective case series, three prospective cross-sectional surveys, a retrospective cohort study, a prospective case series and a prospective randomised control trial.</p><p><strong>Strength of evidence </strong></p><p>Weak</p><p><strong>Outcomes reported</strong></p><p>It would appear that in the United Kingdom the incidence of non-AB transfusion reactions is low.&nbsp; A single study suggests that cross-matching may result in a greater improvement in haematocrit, but this is unlikely to be clinically significant. There is evidence to support the hypothesis that non-AB antigens (for example the Mik antigen) differ with geographic distribution.</p><p><strong>Conclusion</strong></p><p>Based on the information available it is it is challenging to establish a meaningful clinical conclusion on which to base a recommendation.</p><p>&nbsp;</p><p><span style="color: #0000ff;"><a style="color: #0000ff;" href="http://www.ebvmlearning.org/apply/" target="_blank" rel="noopener">How to apply this evidence in practice</a></span></p><p>The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.</p><p>Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.</p><p>&nbsp;</p><p><img src="https://www.veterinaryevidence.org/rcvskmod/icons/oa-icon.jpg" alt="Open Access"> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/pr-icon.jpg" alt="Peer Reviewed"></p> ER -