@article{Teh_Krockenberger_2021, title={Do papillomaviruses cause feline cutaneous squamous cell carcinoma?}, volume={6}, url={https://veterinaryevidence.org/index.php/ve/article/view/402}, DOI={10.18849/ve.v6i3.402}, abstractNote={<p><strong>PICO question</strong></p> <p>In cats infected with papillomavirus, is the risk of developing feline cutaneous squamous cell carcinoma greater than cats that are not infected with papillomavirus?</p> <p> </p> <p><strong>Clinical bottom line</strong></p> <p><strong>Category of research question</strong></p> <p>Risk</p> <p><strong>The number and type of study designs reviewed</strong></p> <p>Eleven papers were critically reviewed, nine were case-control studies and two were experimental in vitro studies</p> <p><strong>Strength of evidence</strong></p> <p>Moderate</p> <p><strong>Outcomes reported</strong></p> <p>Infection of feline epithelial skin cells with <em>Felis catus </em>papillomavirus type 2 (FcaPV-2) is a risk factor for the development of feline cutaneous squamous cell carcinoma. The pathogenesis of FcaPV-2 infection and neoplastic transformation into malignant cells shares similar pathways to the human papillomavirus (HPV) model of pathogenesis and carcinogenesis with some differences</p> <p><strong>Conclusion</strong></p> <p>In conclusion, there is moderate strength of evidence in the literature to support a role of FcaPV-2 in the development of cutaneous squamous cell carcinomas in cats. Therefore, prevention of infection with FcaPV-2 should prevent some cancers</p> <p> </p> <p><span style="color: #0000ff;"><a style="color: #0000ff;" href="https://learn.rcvsknowledge.org/course/view.php?id=2" target="_blank" rel="noopener">How to apply this evidence in practice</a></span></p> <p>The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.</p> <p>Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.</p> <p> </p> <p><img src="https://www.veterinaryevidence.org/rcvskmod/icons/oa-icon.jpg" alt="Open Access"> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/pr-icon.jpg" alt="Peer Reviewed"></p>}, number={3}, journal={Veterinary Evidence}, author={Teh, Alexander and Krockenberger, Mark}, year={2021}, month={Sep.} }